May also deacetylate p53/TP53 and promotes cell survival, however such data need additional confirmation. Stimulates transcription activity of the RNA polymerase I complex. Also required to restore the transcription of ribosomal RNA (rRNA) at the exit from mitosis: promotes the association of RNA polymerase I with the rDNA promoter region and coding region. These data suggest that SIRT7 may play a key role in oncogenic transformation by suppresses expression of tumor suppressor genes by locus-specific deacetylation of H3K18Ac at promoter regions. Moreover, H3K18 hypoacetylation has been reported as a marker of malignancy in various cancers and seems to maintain the transformed phenotype of cancer cells. SIRT7 thereby acts as a transcription repressor. H3K18Ac is mainly present around the transcription start site of genes and has been linked to activation of nuclear hormone receptors. Assignments often include analysis and synthesis of mechanical, thermal, and fluid systems. The mechanical engineer designs machines, devices, various products and control systems, and works with the generation, conversion, transmission, and utilization of mechanical and thermal power. In contrast to other histone deacetylases, displays selectivity for a single histone mark, H3K18Ac, directly linked to control of gene expression. Mechanical engineering is a highly diversified profession. NAD-dependent protein deacetylase that specifically mediates deacetylation of histone H3 at 'Lys-18' (H3K18Ac).
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